Voxel‐Based Morphometry and Voxel‐Based Relaxometry in Parkinsonian Variant of Multiple System Atrophy
Identifieur interne : 000491 ( Main/Exploration ); précédent : 000490; suivant : 000492Voxel‐Based Morphometry and Voxel‐Based Relaxometry in Parkinsonian Variant of Multiple System Atrophy
Auteurs : Loukia C. Tzarouchi ; Loukas G. Astrakas ; Spyridon Konitsiotis ; Sofia Tsouli ; Persefoni Margariti ; Anastasia Zikou ; Maria I. ArgyropoulouSource :
- Journal of Neuroimaging [ 1051-2284 ] ; 2010-07.
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Abstract
ABSTRACT: BACKGROUND AND PURPOSE: Multiple system atrophy (MSA) is a progressive neurodegenerative disorder divided into a parkinsonian (MSA‐P) and a cerebellar variant. The purpose of this study was to assess regional brain atrophy and iron content using Voxel‐based morphometry (VBM) and Voxel‐based relaxometry (VBR) respectively, in MSA‐P. METHODS: Using biological parametric mapping the effect of brain atrophy was evaluated in T2 relaxation time (T2) measurements by applying analysis of covariance (ANCOVA) and correlation analysis to the VBM and VBR data. Eleven patients with MSA‐P (aged 61.9 ± 11.7 years, disease duration 5.42 ± 2.5 years) and 11 controls were studied. RESULTS: In comparison to the controls the patients showed decreased gray matter in the putamen, the caudate nuclei, the thalami, the anterior cerebellar lobes, and the cerebral cortex, and white matter atrophy in the pons, midbrain, and peduncles. VBR analysis showed prolonged T2 in various cortical regions. On ANCOVA, when controlling for gray and white matter volume, these regions of prolonged T2 were shrunk. Negative correlation was demonstrated between T2 and gray and white matter volume. CONCLUSIONS: Diffuse brain atrophy, mainly in the motor circuitry is observed in MSA‐P. Normalization for atrophy should always be performed in T2 measurements.
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DOI: 10.1111/j.1552-6569.2008.00343.x
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Astrakas</name></author><author><name sortKey="Konitsiotis, Spyridon" sort="Konitsiotis, Spyridon" uniqKey="Konitsiotis S" first="Spyridon" last="Konitsiotis">Spyridon Konitsiotis</name></author><author><name sortKey="Tsouli, Sofia" sort="Tsouli, Sofia" uniqKey="Tsouli S" first="Sofia" last="Tsouli">Sofia Tsouli</name></author><author><name sortKey="Margariti, Persefoni" sort="Margariti, Persefoni" uniqKey="Margariti P" first="Persefoni" last="Margariti">Persefoni Margariti</name></author><author><name sortKey="Zikou, Anastasia" sort="Zikou, Anastasia" uniqKey="Zikou A" first="Anastasia" last="Zikou">Anastasia Zikou</name></author><author><name sortKey="Argyropoulou, Maria I" sort="Argyropoulou, Maria I" uniqKey="Argyropoulou M" first="Maria I." last="Argyropoulou">Maria I. 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Argyropoulou</name><affiliation><wicri:noCountry code="subField">MD.]</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neuroimaging</title><idno type="ISSN">1051-2284</idno><idno type="eISSN">1552-6569</idno><imprint><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><date type="published" when="2010-07">2010-07</date><biblScope unit="volume">20</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="260">260</biblScope><biblScope unit="page" to="266">266</biblScope></imprint><idno type="ISSN">1051-2284</idno></series><idno type="istex">AE6F4D69030F53A0CEEEF6858F5A054F54C23C04</idno><idno type="DOI">10.1111/j.1552-6569.2008.00343.x</idno><idno type="ArticleID">JON343</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1051-2284</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Magnetic resonance imaging</term><term>multiple system atrophy</term><term>voxel based morphometry</term><term>voxel based relaxometry</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">ABSTRACT: BACKGROUND AND PURPOSE: Multiple system atrophy (MSA) is a progressive neurodegenerative disorder divided into a parkinsonian (MSA‐P) and a cerebellar variant. The purpose of this study was to assess regional brain atrophy and iron content using Voxel‐based morphometry (VBM) and Voxel‐based relaxometry (VBR) respectively, in MSA‐P. METHODS: Using biological parametric mapping the effect of brain atrophy was evaluated in T2 relaxation time (T2) measurements by applying analysis of covariance (ANCOVA) and correlation analysis to the VBM and VBR data. Eleven patients with MSA‐P (aged 61.9 ± 11.7 years, disease duration 5.42 ± 2.5 years) and 11 controls were studied. RESULTS: In comparison to the controls the patients showed decreased gray matter in the putamen, the caudate nuclei, the thalami, the anterior cerebellar lobes, and the cerebral cortex, and white matter atrophy in the pons, midbrain, and peduncles. VBR analysis showed prolonged T2 in various cortical regions. On ANCOVA, when controlling for gray and white matter volume, these regions of prolonged T2 were shrunk. Negative correlation was demonstrated between T2 and gray and white matter volume. CONCLUSIONS: Diffuse brain atrophy, mainly in the motor circuitry is observed in MSA‐P. Normalization for atrophy should always be performed in T2 measurements.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Argyropoulou, Maria I" sort="Argyropoulou, Maria I" uniqKey="Argyropoulou M" first="Maria I." last="Argyropoulou">Maria I. Argyropoulou</name><name sortKey="Astrakas, Loukas G" sort="Astrakas, Loukas G" uniqKey="Astrakas L" first="Loukas G." last="Astrakas">Loukas G. 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